Natural Cycle IVF with In-Vitro Maturation (IVM)

IVM is a new alternative approach to conventional IVF

In Vitro Maturation (IVM) is a new and exciting development in infertility treatment, which recent scientific publications have shown could be an alternative approach to conventional IVF.

Essentially, we can potentially create more embryos from a Natural Cycle without using stimulating drugs – which means the treatment is safer, less expensive and can potentially have the same advantages of stimulated cycles (i.e. more eggs and embryos from one natural cycle).

CREATE is proud to include Professor RC Chian, a world renowned pioneer of IVM, as our Scientific Director responsible for co-ordinating embryology services.

Once considered a challenge, IVM is now a reality. However, it is still important to individualise natural cycle IVF treatment with or without IVM for different patients in order to optimise success.

Please contact us to make an appointment to discuss Natural Cycle IVF with IVM

Why choose Natural Cycle IVF with IVM?

Natural Cycle IVF/M potentially creates more embryos without stimulating drugs

In Natural Cycle IVF with IVM we aim to collect one mature egg together with several immature eggs. Immature eggs are then matured in the laboratory using special and advanced culture conditions to create several embryos.

Normally, 70-80% of these immature eggs collected from the ovaries will mature 24-48 hours after culture in the laboratory.

Natural Cycle IVF/M can greatly increase success rates

Collecting more eggs with IVM greatly increases the chance of achieving pregnancy as it potentially results in several viable embryos - some of which can be frozen and transferred in a subsequent cycle.

So far, there have been more than 250 healthy babies born worldwide following the collection of immature eggs which were matured with IVM. (Data from Canada, Denmark, France, Korea, Japan, Taiwan and China).

Natural Cycle IVF/M is safer and less expensive than conventional stimulated IVF

In comparison with stimulated IVF treatment, the major advantages of Natural Cycle IVF with IVM include the avoidance of stimulation drugs and their associated side effects such as Ovarian Hyperstimulation Syndrome (OHSS).

The treatment is carried out in a woman’s own menstrual cycle with no suppression from drugs that can cause menopausal symptoms. There is no artificial cycle and women feel that they are in control. The treatment is also less expensive and more simple.

Natural Cycle IVF/M is a successful alternative for women with Polycystic Ovaries (PCO) or Polycystic Ovarian Syndrome (PCOS)

It has recently been demonstrated that immature egg collection followed by IVM is a successful alternative to conventional IVF for women with Polycystic Ovaries (PCO) or Polycystic Ovarian Syndrome (PCOS) related infertility (Chian et al, 1999).

In general, the clinical pregnancy rates are 30-35% in infertile women with PCO or PCOS, based on approximately 1,000 cycles of IVM-treatment.

The Natural Cycle IVF/M Procedure

During each menstrual cycle, usually only a single follicle (egg sac) grows to the ovulation stage to release an egg for potential fertilisation. However, there are several small follicles called antral follicles in the ovary which contain immature eggs.

Please contact us to make an appointment to discuss Natural Cycle IVF with IVM