An introduction to In Vitro Maturation

In Vitro Maturation (IVM) is a revolutionary fertility treatment, which has been pioneered by our Scientific Director, Professor R C Chian. It involves the collection of immature eggs, which are then matured in the lab. By this method, it is possible to collect multiple eggs without giving hormone stimulation. We were the first fertility clinic in Europe to offer Natural Cycle IVF with IVM.

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What is IVM?

During each menstrual cycle, usually only a single follicle (egg sac) grows to the ovulation stage to release an egg for potential fertilisation. However, there are several small follicles called antral follicles in the ovary which contain immature eggs. With IVM these can be collected and matured in the lab. Immature eggs are matured in the laboratory using special and advanced culture conditions to create several embryos.

8 embryo cells

Advantages of Natural IVF Treatment

More embryos
More embryos

Around 70-80% of immature eggs collected from the ovaries will mature 24-48 hours after culture in the laboratory.

Increased success rate
Increased success rate

Creating more embryos can lead to an increased chance of pregnancy.

Healthy babies
Healthy babies

So far, there have been more than 2500 healthy babies born worldwide following the collection of immature eggs which were matured with IVM.

Better implantation
Better implantation

By avoiding stimulating drugs, the womb is more receptive to pregnancy.

Healthier babies
Healthier babies

There is also evidence that babies born with Natural Cycle IVF are more likely to be born at full term and with a healthier birth weight.

Safer for women
Safer for women

Natural Cycle IVF with IVM avoids the effects of  stimulation drugs and eliminates the risk of Ovarian Hyperstimulation Syndrome (OHSS).

Giving all women a chance
Giving all women a chance

We do not have any selection criteria and have successfully treated hundreds of women with critically low ovarian reserve/low AMH/high FSH.

More affordable
More affordable

Natural IVF is less expensive per cycle than Stimulated IVF treatments as it does not require costly medication.

Who is suitable for this Treatment?

This treatment can be used for anyone who is ovulating and who is recommended to do IVM by one of our doctors. It can be particularly useful for people for whom time is short, or who are unable to take fertility medication (due to an oestrogen dependent tumour for example). 

Natural Cycle IVF with IVM is also a successful alternative for women with Polycystic Ovaries (PCO) or Polycystic Ovarian Syndrome (PCOS). In general, the clinical pregnancy rates are 30-35% in infertile women with PCO or PCOS, based on approximately 1,000 cycles of IVM-treatment. 

'A combination of three things attracted me to CREATE.'

The first one was their more natural and less invasive approach to IVF with reduced amount of drugs. Number two was the quality of their internationally renowned consultants, and number three was their treatment cost. Whilst success rates was also a factor of choice, it was not as important a criteria to me as I first anticipated when I found out the reported figures were often reflective of the clinics’ unwillingness to accept patients with very low chance of success and therefore could not be compared on a like-for-like basis.
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From one of our fertility experts